Research Articles and Reviews

Weinberg B.H., Pham N.T.H., Caraballo L.D., Lozanoski T., Engel A., Bhatia S., Wong W.W.  Large-scale design of robust genetic circuits with multiple inputs and outputs for mammalian cells (2017). Nature Biotechnology. 

      Datasheets for the 113 circuits describe in Figure 3 (Website developed by Prof. Swapnil Bhatia)

News coverage:
      WIRED article on “Scientists Hack a Human Cell and Reprogram It Like a Computer”
      Science article on “Scientists turn mammalian cells into complex biocomputers” article on “Programming human cells to follow sets of logical instructions”
      Futurism article on “New Research Turns Mammalian Cells Into Biocomputers”
      BU Engineering News article on “How to Hack a Cell”

Brenner M, Cho JH, Wong WW. (2017) Synthetic biology: Sensing with modular receptors. Nat Chem Biol. 2017 Jan 19;13(2):131-132.

Aquino P, Honda B, Jaini S, Lyubetskaya A, Hosur K, Chiu JG, Ekladious I, Hu D, Jin L, Sayeg MK, Stettner AI, Wang J, Wong BG, Wong WS, Alexander SL, Ba C, Bensussen SI, Bernstein DB, Braff D, Cha S, Cheng DI, Cho JH, Chou K, Chuang J, Gastler DE, Grasso DJ, Greifenberger JS, Guo C, Hawes AK, Israni DV, Jain SR, Kim J, Lei J, Li H, Li D, Li Q, Mancuso CP, Mao N, Masud SF, Meisel CL, Mi J, Nykyforchyn CS, Park M, Peterson HM, Ramirez AK, Reynolds DS, Rim NG, Saffie JC, Su H, Su WR, Su Y, Sun M, Thommes MM, Tu T, Varongchayakul N, Wagner TE, Weinberg BH, Yang R, Yaroslavsky A, Yoon C, Zhao Y, Zollinger AJ, Stringer AM, Foster JW, Wade J, Raman S, Broude N, Wong WW, Galagan JE. (2017). Coordinated regulation of acid resistance in Escherichia coli. BMC Systems Biology, 11(1):1.

Bowyer J., Zhao J., Subsoontorn P., Wong W.W., Rosser S., Bates D. (2016). Mechanistic Modeling of a Rewritable Recombinase Addressable Data Module. IEEE Transactions on Biomedical Circuits and Systems, 99: 1-10. 

Chakravarti D., Cho J.H., Weinberg B.H., Wong N.M., & Wong W.W. (2016) Synthetic biology approaches in cancer immunotherapy, genetic network engineering, and genome editing. Integrative Biology,  18;8(4):504-17. 

Chakravarti, D., & Wong, W. W. (2015). Synthetic biology in cell-based cancer immunotherapy. Trends in Biotechnology, 33(8), 449–461. 
      Cell podcast on “How synthetic biology can contribute to new approaches to cancer treatment. 9:15”

Sayeg, M. K*., Weinberg, B. H*., Cha, S. S., Goodloe, M., Wong, W. W.#, & Han, X#. (2015). Rationally Designed MicroRNA-Based Genetic Classifiers Target Specific Neurons in the Brain. ACS Synthetic Biology, 150413154538000. doi:10.1021/acssynbio.5b00040 (*Co-first author, #Co-corresponding author)

Wei, P*., Wong, W.W*., Park, J.S., Corcoran, E. E., Peisajovich, S. G., Onuffer, J, J., Weiss, A., Lim, W.A.  2012. Using bacterial effector proteins as tools to rewire MAPK signaling in yeast and immune cells.  Nature. 488: 384-388. (*co-first author)

Wong, W.W., Liao, J.C.  2009.  Microbial maximal specific growth rate as a square-root function of biomass yield and two kinetic parameters.  Metabolic Engineering. 11(6):409-14

Wong, W.W., Tran, L.M., Liao, J.C. 2009.  A hidden square-root boundary between growth rate and biomass yield.  Biotechnology and Bioengineering. 1(102): 73-80.

Wong, W.W., Tsai T.Y., Liao, J.C. 2007.  Single-cell zeroth-order protein degradation enhances the robustness of synthetic oscillator.  Molecular Systems Biology. 3(130): 1-8.

Xie, X., Wong, W.W., Tang, Y. 2007. Improving simvastatin bioconversion in Escherichia coli by deletion of bioH. Metabolic Engineering.  9(4): 379-386.

Wong, W.W., Liao, J.C. 2006.  The design of intracellular oscillators that interact with metabolism.   Cellular and Molecular Life Science.  63(11): 1215-1220.

Brynildsen, M.P., Wong, W.W., Liao, J.C. 2005. Transcriptional regulation and metabolism.  Biochemical Society Transactions. 33(6): 1423-1426.

Fung, E., Wong, W.W., Suen, J.K., Bulter, T., Lee, S., Liao, J.C. 2005.  A synthetic gene-metabolic oscillator.  Nature. 435(5): 118-122.

Bulter, T., Lee, S., Wong, W.W., Fung, E., Connor, M. and Liao, J.C. 2004. Design of artificial cell-cell communication for gene and metabolic circuits. Proceedings of the National Academy of Science, USA. 101(8): 2299-2304.

Wong, W.W., and Newman, J.S.  2002.  Monte Carlo Simulation of the Open-Circuit Potential and the Entropy of Reaction in Lithium Manganese Oxide.  Journal of the Electrochemical Society. 149(4): A493-A498.

Wang, J., Chun, H.J., Wong, W.W., Spencer, D.M., and Lenardo, M.J.  2001. Caspase-10 is an initiator caspase in death receptor signaling. Proceedings of the National Academy of Science, USA. 98(24): 13884-13888.

Book Chapters

Wong, W.W., Liao, J.C.  2010. A Synthetic Approach to Transcriptional Regulatory Engineering. The Metabolic Pathway Engineering HandbookFundamentals, CRC Press, Chapter 14.

Wong, W.W., Liao, J.C.  2009. The Synthetic Approach for Regulatory Circuits and Metabolism.  Systems Biology and Synthetic Biology, John Wiley & Sons, Chapter 14.