The Wong lab is interested in applying synthetic biology to rapidly and predictably engineer desired properties in human immune cells to treat diseases. One area that we interested in is engineering genetic circuits to improve the efficacy and safety of adoptive T cell therapy. You can learn more about our effort in synthetic biology at BU from the following video.
Here we are interested in using synthetic biology to design and construct novel signaling, transcription, and metabolic networks in cells for
1. Application in medicine and
2. Understanding design principles in living organisms.
Specifically, we are interested in engineering human immune cells for adoptive cancer immunotherapy. Adoptive immunotherapy is a promising therapy for treatment of various cancers (1).
Our goal at the Wong Lab is to engineer immune cells to enhance their disease fighting capability while minimizing adverse side effect. Also, by building novel networks inside immune cells, we can explore design principles by mapping network architecture to phenotype.
(1) N Engl J Med. 2011 Aug 25;365(8):725-33. Epub 2011 Aug 10.